Utilizing Haemagglutination Property of Rabies Virus for Detecting the Pathogen and Checking its Destabilization
Keywords:HI, laboratory diagnosis, rabies, SSDHI, virion integrity
The haemagglutination property of viruses is useful for titration and condensation of virions of their own, as well as for titration specific antibodies to them, but detection of the pathogens in clinical samples. However, on the base of the haemagglutination (HA) and haemagglutination inhibition (HI) titration techniques a derivative technique was recently contrived for detection of haemagglutinating viruses in animals called the method of Assay of Shifting of Standardized Direct Haemagglutination Inhibition, or SSDHI. We herein report on the application of these HA-based techniques in cases of rabies virus. With pictorial evidences in detecting the microbe in saliva fluids of furious and healthy dogs in Central Vietnam for disease diagnosis and epidemiological investigation, some results on detection of rabies virus in clinical samples, criteria of discrimination of â€œcoinfectionsâ€ with other haemagglutinating viruses and possible â€œcontaminationsâ€ with specific antibodies or their analogues in clinical samples were discussed. The techniques did also help prove that air-dried virions of rabies virus from clinical samples can sustain their integrity at room temperature at least for two days which implies possibility of the pathogenâ€™s transmission through aerosols.
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