Ameliorative Effect of L-Carnitine against Hematological and Hepatorenal Alterations Induced by Cefquinome Sulfate in Male Albino Rats

Abstract

The present study was conducted to evaluate the ameliorative effect of L-carnitine (LC) against possible deleterious effects of cefquinome sulfate (CS) on hematological, hepatorenal parameters and histopathological changes of some internal organs in male rat's model. Therefore, sixty mature male rats were equally assigned into four groups as following: The control group of rats was administered with two subcutaneous (SC) injections of physiological saline (vehicle of other drugs) (2ml/kg. b.wt once daily for 5 successive days and 2ml/kg. b.wt once daily for 56 successive days), the second group was injected subcutaneously with LC (200 mg/kg b.wt. once daily for 56 successive days), the third group was administered with SC injection with CS (50 mg/kg. b.wt once daily for 5 successive days) and the fourth group was injected subcutaneously with CS concomitantly with LC by the same doses at the same treatment periods as mentioned in 2^nd and 3^rd groups. The obtained results showed that administration of CS induced a significant (P≤ 0.05) increase in WBCs count and serum levels of alanine amino transferase, alkaline phosphatase and creatinine with significant (P≤ 0.05) decrease in PCV value and serum levels of albumin. Moreover, CS induced histopathological changes on liver and kidney tissues. Conversely, administration of LC concomitantly with CS ameliorates all previous hematological, biochemical, and histopathological alterations induced by CS. It could be concluded that CS induces mild to moderate troubles on blood picture, hepato-renal indices and histopathological findings which could be ameliorated by L-carnitine in male albino rats.