Assessment of Cutaneous Wound Healing Potential of Hyaluronic Acid and Chitosan in Dogs

Authors

  • Soheir E. Morsy Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Cairo University, Cairo 11865, Egypt.
  • Ahmed S. Soliman Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Cairo University, Cairo 11865, Egypt.
  • Inas N. El-Husseiny Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Cairo University, Cairo 11865, Egypt.
  • Faten F. Mohammed Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Cairo 11865, Egypt.
  • AbdulRahman A. Saied Ministry of Tourism and Antiquities, Aswan Office, Aswan 81511, Egypt.
  • Alsayed A. Mohamed Department of Anatomy and Embryology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt.
  • Asmaa A. Metwally Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528, Egypt.

Keywords:

Cutaneous wound healing, Histologic score, Hyaluronic acid, Chitosan, canine, Wound contraction, Tensile strength

Abstract

Several new topical products have been applied to enhance wound healing and reduce scar formation. The present study aimed to evaluate the potential of the topically applied hyaluronic acid (HA) serum and chitosan (CH) gel for skin wound healing in dogs. Ten adult mongrel dogs were divided into two groups (n = 5 for each). Experimental skin wounds were created in all animals. Eight full-thickness round skin wounds of 2 cm diameter were made on both sides (four for each side) over the dog's dorsal area, where the left side wounds were kept as a control and treated with saline solution only. HA serum and CH gel were used to treat the right-side wounds in the first and second groups, respectively. Wound healing was evaluated clinically and histologically at the 7th, 14th, and 21st days post-treatment. In addition, the tensile strength was measured in both treated wound groups and compared with the control wounds and the normal skin. The results showed that HA-treated wounds exhibited higher wound contraction and better tensile strength compared with CH-treated group. In addition, the histological findings of HA-treated wounds showed marked improvement in histological repair scores compared with CH-treated ones. We concluded that topical HA in a serum formulation provided better skin wound healing compared to CH-treated group.

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Published

2023-10-03

How to Cite

Morsy, S. E. ., Soliman, A. S. ., El-Husseiny, . I. N., Mohammed, F. F. ., Saied, A. A. ., Mohamed, A. A. ., & Metwally, A. A. (2023). Assessment of Cutaneous Wound Healing Potential of Hyaluronic Acid and Chitosan in Dogs. Journal of Advanced Veterinary Research, 13(8), 1626-1633. Retrieved from https://advetresearch.com/index.php/AVR/article/view/1490

Issue

Section

Original Research