Lipid Profile and Obese Related Genes of Rats, Potential Therapeutic Effects of Peganum Harmala /Zinc Oxide Nanoparticles

Authors

  • Mervat Abdelsattar Department Physiology and Zoology, Faculty of Science, Zagazig University, Egypt.
  • Youssef Elseady Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
  • Walaa F. Awadin Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
  • Ahmed Hendawy Department Physiology and Zoology, Faculty of Science, Zagazig University, Egypt.
  • Abd EL-Aziz A. Diab Department Physiology and Zoology, Faculty of Science, Zagazig University, Egypt.

Keywords:

Obesity, Methanolic extract of P. harmala seed, ZnO nanoparticles

Abstract

The present study investigated the effects of methanolic extract of harmala nanoparticle (H/ZnONP) on the changes in serum lipid profiles, serum leptin levels and liver and kidney PPAR gene expression in high caloric diet (HCD) induced obese rats. After induction of obesity with HCD for one month to half numbers of rats. Non-obese group had three subgroups; G1: Control fed basal diets, G2: basal diets plus H/ZnONPs (200 mg/kg/day) and G3: basal diets plus H/ZnONPs (400 mg/kg/day). However, obese group was divided into three subgroups G4: HFD, G5: HFD+H/ZnONPs (200 mg/kg/day) and G6: HFD+ H/ZnONPs (400 mg/kg/day). After 4 weeks of treatment blood and tissue samples were collected and subjected to laboratory assay of lipid profile and leptin level in addition to expression of PPAR gene in liver and kidney. We also investigated the possible protective effect of H/ZnONP 200 and 400 mg/kg BW on liver and kidney histology. The obtained results demonstrated that H/ZnONP treatment to obese rats significantly decreased serum cholesterols, triglyceride, and LDL level while relative expression of PPAR gene in liver and kidney was significantly increased. Based on the obtained results we can concluded that H/ZnONP supplementation has a potent anti-obesity effect in rats by improving lipid profile, enhance expression of PPAR gene in liver and kidney and improve liver and kidney histology particularly the high dose.

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Published

2023-11-20

How to Cite

Abdelsattar , M. ., Elseady, Y. ., Awadin, W. F., Hendawy, A. ., & Diab , A. E.-A. A. (2023). Lipid Profile and Obese Related Genes of Rats, Potential Therapeutic Effects of Peganum Harmala /Zinc Oxide Nanoparticles. Journal of Advanced Veterinary Research, 13(9), 1864-1870. Retrieved from https://advetresearch.com/index.php/AVR/article/view/1527

Issue

Vol. 13 No. 9 (2023): Special Issue: The 12th International Scientific Conference, Faculty of Veterinary Medicine, Mansoura University, Egypt (17-20 September 2023)

Section

Original Research

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Copyright (c) 2023 Journal of Advanced Veterinary Research

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