Renoprotective potential of olive leaves extract against cadmium-induced chronic kidney damage

Authors

  • Sara Badawy Department of Pathology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt. https://orcid.org/0000-0002-7579-7486
  • Muhamad Abd-Elraouf Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
  • Mahmoud S.A. Gab-Allah Department of Pathology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt.
  • Abdel-Baset I. El-Mashad Department of Pathology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt.
  • Ahmed A. Tantawy Department of Pathology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt.
  • Aziza A. Amin Department of Pathology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt.

Keywords:

CdCl2, OLE, Kidney function test, Histopathology, Chronic renal injury

Abstract

Environmental pollution remains a major global health concern, particularly when it comes to heavy metals, which are associated with various health hazards. Among the prevalent heavy metals in the environment is cadmium (Cd). As a result, the current study aimed to investigate the nephroprotective potential of olive leaves extract (OLE) against Cd-induced chronic renal injury. Forty-eight albino rats were divided into four equal groups. Rats in the control group were received distilled water orally, while those in the OLE group were orally administered OLE 200 (mg/kg b.wt.) daily. The cadmium-intoxicated group rats were orally gavage 5 mg Cd/kg b.wt. twice a week and the OLE+Cd group received the same doses of both OLE and CdCl2. After 4 and 8 weeks of the experiment, blood and kidney samples were collected for analysis of kidney function test and histopathological examination. Oral administration of cadmium chloride (CdCl2) for 4 and 8 weeks resulted in nephrotoxicity, evidenced by a significant increase (P<0.05) in urea, uric acid, and creatinine levels. These biochemical changes were accompanied by distinct histopathological alterations, including renal hemorrhage, edema and vasculitis with severe glomerular and tubular necrosis as well as periglomerular fibrosis and marked interstitial fibrosis. Treatment with OLE exhibited a remarkable reduction in these histopathological changes and restored the serum parameters toward normal levels. In conclusion, OLE has a time-dependent mitigating effect against Cd-induced nephrotoxicity by reducing inflammation, glomerulotubular injury, and renal fibrosis, indicating that it is a potential natural product in counteracting chronic nephrotoxicity.

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Published

2023-12-31

How to Cite

Badawy, S., Abd-Elraouf, M. ., Gab-Allah , M. S., El-Mashad, A.-B. I. ., Tantawy, A. A. ., & Amin, A. A. . (2023). Renoprotective potential of olive leaves extract against cadmium-induced chronic kidney damage. Journal of Advanced Veterinary Research, 14(1), 65-70. Retrieved from https://advetresearch.com/index.php/AVR/article/view/1591

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Section

Original Research

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