Moringa Oleifera Ameliorates Cardiotoxicity and Improves Antioxidants in Breast Cancer- induced Rats Treated with Doxorubicin: A Preliminary Study.

Authors

  • Rehab A.M. Gouda Department of Biochemistry, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
  • Abeer G. Ali Hassan Department of Biochemistry, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
  • Yasmina K. Mahmoud Department of Biochemistry, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
  • Ibrahim A. Ibrahim Department of Biochemistry, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.

Keywords:

Antioxidants, Cardiotoxicity, Moringa Oleifera nanoemulsion, Nanoparticles , Tumor markers

Abstract

Moringa Oleifera (MO) is a miracle plant of huge medical significance. It could be used to suppress the aggressiveness of various tumors as well as ameliorate the consequences of chemotherapeutic agents. In the present study; 49 albino rats were used to evaluate the effect of MO nanoparticles (MONPs) in DMBA-induced breast cancer rats (BC-induced) treated with doxorubicin (DOX). Cardiotoxicity, antioxidant markers, and protein profile were evaluated. Serum and mammary glands samples were collected for both biochemical and histopathological examinations. Rats were classified into control and BC-induced rats. The last group was further divided into 6 groups to evaluate the synergistic and prophylactic effects of MONPs. There was a significant reduction in the levels of tumor, and cardiotoxicity markers with a significant increase in the antioxidants/oxidants and proteins profile in BC-induced rats treated synergistically or/and prophylactically with MONPs and DOX. In conclusion, the prophylactic use of MONPs and synergistic use of MONPs and DOX induced a magnificent resistance against cardiotoxicity induced by doxorubicin and ameliorated the aggressiveness of breast cancer as well as the oxidative stress induced in rats.

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Published

2023-12-12

How to Cite

Gouda, R. A., Hassan, A. G. A. ., Mahmoud, Y. K. ., & Ibrahim, I. A. (2023). Moringa Oleifera Ameliorates Cardiotoxicity and Improves Antioxidants in Breast Cancer- induced Rats Treated with Doxorubicin: A Preliminary Study. Journal of Advanced Veterinary Research, 13(10), 1982-1988. Retrieved from https://advetresearch.com/index.php/AVR/article/view/1605

Issue

Vol. 13 No. 10 (2023): Special Issue: The Fifth Conference for the Faculty of Veterinary Medicine, Suez Canal University, Egypt (Food Safety and Animal Health)

Section

Original Research

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Copyright (c) 2023 Journal of Advanced Veterinary Research

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