Assessment the efficacy of some herbes in the prevention of steroid induced hepatopathy in dog

Authors

  • Nehal Elhosiny Directorate of Veterinary Medicine, Ismailia Governorate, Egypt.
  • Abdel Raouf M. Mahmoud Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Egypt.
  • Hatem M. Selim Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Egypt.
  • Heba Gouda Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Egypt.

Keywords:

Haemato-biochemical alterations , Medicinal plants , Steroid , hepatopathy , Ultrasonography

Abstract

Medicinal plants play a crucial role in the treatment and prevention of steroid- induced hepatopathy. The purpose of the study was to evaluate the ability of some herbes to reduce the steroid- induced hepatopathy. Twenty mongrel dogs were included in the experimental study. Dogs were divided into four groups each group consisting of five animals; Group I received dexamethasone, Group II received dexamethasone and concentrated milk thistle (silymarin), Group III received dexamethasone and L-carnitine, Group IV received dexamethasone and liquorice powder. Clinical, blood samples, ultrasound were done on days 0, 7, 14 and 21. Haemato- biochemical analysis  indicated a significant increase in hemoglobin (Hb) concentration and hematocrit value, a significant decrease in white blood cells count, a significant decrease in alkaline phosphatase (ALP) activity and a significant increase in total protein and albumin levels in silymarin treated Group II, L-carnitine treated Group III and liquorice treated Group IV compared to Group I. Ultrasonography revealed an increase in echogenicity of liver parenchyma in hepatopathic induced dogs and returned to nearly normal in Group II and Group III. In conclusion, the medicinal plants have a potential effect in treatment and prevention of steroid induced hepatopathy.

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Published

2024-03-20

How to Cite

Elhosiny, N. ., Mahmoud, A. R. M. ., Selim, H. M. ., & Gouda, H. . (2024). Assessment the efficacy of some herbes in the prevention of steroid induced hepatopathy in dog . Journal of Advanced Veterinary Research, 14(3), 521-525. Retrieved from https://advetresearch.com/index.php/AVR/article/view/1706

Issue

Vol. 14 No. 3 (2024): Special Issue: The 18th Scientific Conference, Faculty of Veterinary Medicine, Zagazig University (Veterinary Medicine and One Health in Light of Climate Changes)

Section

Original Research

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license