Competence of Panax ginseng on Male Fertility in Cypermethrin Exposed Rats

Abstract

The rising occurrences of male reproductive disorders, as decreased semen (quality and quantity) and testicular cancer, are of great concern for animal production. Therefore, this study was conducted to determine the toxic impact of cypermethrin on the fertility of male rats. Other goal was using the Panax ginseng as androgenic drug for reducing the negative impact of cypermethrin poisoned rats. In the results, oral LD₅₀ of cypermethrin in mature male rats was found to be 374.633 ±12.187 mg/kg. Based on that, thirty-two adult male rats were equally divided into four groups. Group (1) served as –ve control; group (2) treated with 0.1% Panax in feed and kept as +ve control; group (3) orally dosed 1/40 LD₅₀ of cypermethrin; and group (4) intubated the same dose of cypermethrin and panax admixed with diet for 60 days. The results demonstrated that cypermethrin generated obvious disorders in male fertility as evidenced by a significant decrease in the blood testosterone, LH and FSH hormones, testes weights, sperm count and motility, and live sperm percentage. Sperm cell abnormalities were significantly elevated in cypermethrin poisoned rats compared. Although the group treated by cypermethrin with panax showed a lesser effect. Cypermethrin intoxication showed sever alteration in fertility indices and fetal values. Histopathological examinations on the testes, seminal vesicles, and prostate glands served as confirmation for all findings. A positive control group didn’t significantly differ as compared to a negative control. Otherwise, it recorded the best results in percentage of motile and live sperm, especially drops of sperm cell abnormalities. Results concluded that involvement with cypermethrin caused overt defects in male reproductive function, which were cured by administering the androgenic drug Panax.