Immunomodulatory effects of Oregano and Artichoke based pharmaceuticals on Barki ewes' immune response to sheep pox vaccine
Keywords:
Sheep pox vaccine, Neutralization index, Clinicopathological alterations, Oregano Extract, Artichoke Extract.Abstract
Lately, there's been a growing recognition of the therapeutic potential of natural plant extracts. These extracts have shown promise in treating a range of diseases and in partially mitigating the oxidative stress often linked with illnesses or the use of antibiotics. This work studied the effect of two pharmaceutical products based on plant extracts on the humoral and innate immune response of Barki ewes to the Sheep pox Vaccine. For this purpose, 15 Barki ewes were injected with the life-attenuated pox vaccine only (Pox group), 15 Barki ewes were injected with the same vaccine and orally treated with 50ml/head of Immune Care® (based oregano extract) for 5 consecutive days, (Immune Care Group (IG)), 15 Barki ewes were injected with the same vaccine and orally treated with 50ml/head of Bovi Care® (based on artichoke) for 5 consecutive days. Blood samples were collected from them, NI and innate immunity, and clinicopathological parameters were estimated and statistically analyzed. Immune Care® and Bovi Care® didn`t improve the humoral immune responses of vaccinated ewes to the vaccine. However, they maintained the vaccinated ewes' total antioxidant capacity, erythrocyte counts, and total protein levels within normal ranges. Furthermore, they exhibited better values in serum renal and hepatic function tests, neutrophil phagocytic index, albumin, and globulin. Conclusion: Immune Care® and Bovi Care® did not have any effect on the humoral immune response of the Barki ewes to the pox vaccine but they effectively mitigated some of its side effects.
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license