Anti-inflammatory Activity of Eugenia jambolana and Trigonella foenum graecum in Experimental Animal Model

Abstract

The present study was carried out to evaluate the anti-inflammatory effect of Eugenia jambolana and Trigonella foenum graecum in abino rats. Animals were classified into seven groups; T1 served as vehicle control, which received 0.1 ml gum acacia, while T2 received acetylsalicylic acid at 150 mg/kg orally. The ethanolic extract of E. jambolana in gum acacia was administered orally in groups T3 and T4 at 100 and 200 mg/kg orally respectively. Aqueous extract of T. f. graecum in gum acacia was administered orally at a dose rate of 100 mg/kg, 200 mg/kg and 400 mg/kg to T5, T6 and T7 respectively. Paw oedema was induced by injecting 0.1 ml of 1% (w/v) carrageenan sub-cutaneously (s/c). The percentage inhibition of oedema in T2, T3, T4, T5, T6 and T7 were observed to be 62, 43, 64, 57, 58 and 62 percent respectively. The results of the present study revealed that the treatment groups showed a significant reduction in paw volume in a dose dependent manner indicating their anti-inflammatory action, which had provided a proof for the scientific validation of their ethno pharmacological property.