The Protective Effect of Silymarin against Ochratoxin A Induced Histopathological and Biochemical Changes in Chicks

Authors

  • Stoycho Stoev Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria.
  • Teodora Mircheva Department of Biochemistry, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria.
  • Stefan Denev Department of Biochemistry and Microbiology, Faculty of Agriculture, Trakia University, Students campus, 6000 Stara Zagora, Bulgaria.
  • Sashka Chobanova Department of Biochemistry and Microbiology, Faculty of Agriculture, Trakia University, Students campus, 6000 Stara Zagora, Bulgaria.
  • Veselin Ivanov Department of Neurology and Psychiatry, Faculty of Medicine, Trakia University, Students campus, 6000 Stara Zagora, Bulgaria.

Abstract

Protective effects of herbal feed additive Silymarin against the deleterious toxic effects of ochratoxin A (OTA) on internal organs and blood biochemistry was seen. The observed histopathological and biochemical changes were well expressed in OTA-exposed chicks without Silymarin supplementation, followed by chicks treated supplementary with Silymarin in addition to OTA treatment, whereas no pathological changes were seen in the control chicks or the chicks treated with Silymarin only. The observed increase in the serum levels of uric acid, glucose and the enzyme activity of AST and ALT in OTA treated chicks and the found decrease of the same biochemical indices in the chicks protected by Silymarin in addition to OTA treatment also supported the protective effects of this herbal additive on the kidneys and liver. The same herbal substance Silymarin could be used as a practical approach for safely utilizing of OTA-contaminated feed.

Key words: ochratoxin A, protection, herbal additive, Silymarin, blood biochemistry, pathomorphology

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Published

2021-01-06

How to Cite

Stoev, S., Mircheva, T., Denev, S., Chobanova, S., & Ivanov, V. (2021). The Protective Effect of Silymarin against Ochratoxin A Induced Histopathological and Biochemical Changes in Chicks. Journal of Advanced Veterinary Research, 11(1), 1-8. Retrieved from https://advetresearch.com/index.php/AVR/article/view/598

Issue

Vol. 11 No. 1 (2021): January

Section

Original Research

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Copyright (c) 2021 Journal of Advanced Veterinary Research

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