Clinicopathological Studies on the Effect of Nano Selenium Particles in Broilers

Abstract

The reason for this research was to analyze the potential immune-stimulating and antioxidant properties of nano-selenium (nano-Se) in broiler chickens. The study utilized 150 one-day-old Cobb broiler chickens, which were arbitrarily allocated to six groups of 25 chickens every: G1 (control), G2 (0.3 ml nano-selenium/L water), G3 (0.5 ml nano-selenium/L water), G4 (E. coli 2 x 10⁷ cfu), G5 (0.3 ml nano-selenium/L water and E. coli), and G6 (0.5 ml nano-selenium/L water and E. coli). Various immune response, antioxidant, and oxidative stress parameters were evaluated. The results revealed that infected chickens had significantly lower levels of immunoglobulins (IgG, IgM, IgA), glutathione peroxidase (GPX), superoxide dismutase (SOD), and interleukin-4 (IL-4) compared to the control group. Conversely, the infected chickens revealed a marked higher in interleukin-2 (IL-2), interferon-gamma (IF-γ), and malondialdehyde (MDA). In contrast, infected and nano-se treated chickens exhibited a rise in IgG, IgM, IgA, GSH, GPX, SOD, and IL-4 with a notable decline in IF-γ, IL-2, and MDA relative to the infected group. These findings suggest that nano-se may play a significant role in immune response, antioxidant activity, and control and prevention of E. coli infections in broiler chickens. These results imply that nano-se may have a substantial role in strengthening the immune response, antioxidant activity, and management and prevention of E. coli infections in broiler chickens.Bottom of Form