Protective Effect of Avenanthramides against Cisplatin Induced Testicular Degeneration in Rats
Keywords:Avenanthramides, Cisplatin, Oxidative stress, Testicular damage
This study was performed to evaluate the protective effect of Avenanthramides (AVA) against testicular degeneration induced by cisplatin (CP) in rats. Thirty six male rats were equally divided into four groups: Group I served as control group, group II received intraperitoneal injection of CP at a dose of 7 mg/kg b.wt., group III received AVA (20 mg/kg b.wt.) daily for one week before injection of CP, group IV received only AVA. Administration of CP reduced sperm count, motility and viability, testicular weight and epithelial height. CP administration increased sperm DNA damage and malondialdehyde (MDA) level. The level of glutathione peroxidase and testosterone hormone were decreased in CP group. Severe histopathological changes in testes of CP exposed rats were prominent. On the other hand, administration of AVA could improve the sperm viability, sperm count and testicular weight and reduced the degree of DNA damage in sperms. AVA reduced the level of MDA and the histopathological changes in testes. In conclusion, AVA can reduce the oxidative stress and ameliorate the degenerative changes in testes induced by CP.
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