Antioxidant and Histopathological Effect of Galantamine Against Paracetamol-Induced Side Effect

Authors

  • Gamal Shams Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44519 Zagazig, Egypt.
  • Shahd El-Mesiry Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44519 Zagazig, Egypt.

Abstract

The goal of this research was to find out more about the possible protective role of galantamine (GAL) (0.3 mg/kg P.O) for 28 successive days against paracetamol (PCM) toxicity that was administrated on day 29 of the experiment, at day 30, blood sample were collected for evaluation of antioxidant enzymes and tissues for histopathological studies. Oxidative stress biomarkers which included serum superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde and histopathological studies indicated that GAL has protective effects by prohibiting the improvement in oxidative stress biomarkers and improved the histopathological lesions seen in livers and kidneys in vivo model against hepatic and renal toxicity induced by PCM in rats.

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Published

2022-09-17

How to Cite

Shams, G. ., & El-Mesiry, S. . (2022). Antioxidant and Histopathological Effect of Galantamine Against Paracetamol-Induced Side Effect. Journal of Advanced Veterinary Research, 12(4), 358-362. Retrieved from https://advetresearch.com/index.php/AVR/article/view/1014

Issue

Vol. 12 No. 4 (2022): Special Issue (Food Safety and Human Health: Egypt vision 2030, Badr University, Egypt)

Section

Original Research

License

Copyright (c) 2022 Journal of Advanced Veterinary Research

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license