Wound Healing Activity of Brown Algae plus Polyherbal Extract in Normal and Alloxan-induced Diabetic Rats

  • Fedekar F. Madkour
  • Mohsen M. Hassan
  • Walied Abdo
  • Waleed F. Khalil

Abstract

The aim of the present study was to assess the wound healing efficacy of the experimental medicinal extract mixture (EMEM) composed of brown algae, Cystoseira trinodis, plus three medicinal plants (garlic, liquorice and ginger). The extract was applied on induced excised wounds in rats, either healthy or induced hyperglycemia by alloxan. Healing activity was evaluated for up to 21 days after wounding in terms of decrease in surface area of wound, percentage of wound closure and tissue regeneration using digital planimetry analysis and histopathological examination. The study revealed that topical application of the extract improved and enhanced the healing process in diabetic rat model when compared with diabetic non-treated rats. The extract promoted wound contraction, reduced the wound closure time and induced proliferation of fibroblast as well as angiogenesis and re-epithelialization.

Published
2013-07-01
How to Cite
MADKOUR, Fedekar F. et al. Wound Healing Activity of Brown Algae plus Polyherbal Extract in Normal and Alloxan-induced Diabetic Rats. Journal of Advanced Veterinary Research, [S.l.], v. 3, n. 3, p. 102-108, july 2013. ISSN 2090-6277. Available at: <https://advetresearch.com/index.php/AVR/article/view/126>. Date accessed: 20 june 2019.
Section
Original Research