Mitigative Effect of Dietary Tinospora cordifolia and Andrographis paniculata on Health and Hepato-renal Expression of Caspase-3 and TNF-α of Broiler Chickens Fed on Aflatoxin and Ochratoxin Contaminated Diet

Authors

  • Rabie H. Fayed Animal and Poultry Management, Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
  • Eman Rashad Department of Cytology and Histology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
  • Salma I. El-Samannoudy Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt
  • Hany M.R. Elsherif Department of Animal Production, Faculty of Agriculture, Cairo University, Giza 12613, Egypt
  • Hassan Aboul Ella Department of Microbiology and Mycology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt
  • Elshaimaa Ismael Animal, Poultry, and Environmental Hygiene, Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt. https://orcid.org/0000-0002-3991-2846

Keywords:

Aflatoxin, Ochratoxin, Tinospora cordifolia, Andrographis paniculata, Caspase-3

Abstract

Medicinal herbs are modern feed additives for poultry that have antioxidant, anti-microbial, and immune-modulatory impacts. In this study, the protective effects of medicinal natural herbs (Herb-AllTM LIVER) on performance, litter, immunity, biochemical changes, and histopathological changes in broilers fed Mycotoxins-contaminated diets were assessed. One-day-old chicks were randomly assigned into 4 groups (n=120). Group A was fed a standard commercial diet; Group B was fed a standard diet + (Herb-AllTM LIVER); Group C (positive control) was fed a Mycotoxins-contaminated diet, and Group D received a Mycotoxins-contaminated diet + Herb-AllTM LIVER. Performance, litter hygiene, immunity, and histopathological changes were determined. Results indicated that herbal supplements (B and D) significantly improved the body weight gain and FCR of birds. Also, litter hygiene, blood indices, antibody titers, and organ functions were enhanced. In group D, liver and kidney histological architectures were mostly restored, as well as Caspase-3 and TNF expressions were moderately enhanced. It can be concluded that using Herb-AllTM LIVER as a feed additive reduces the adverse effects of Mycotoxins on broilers.

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Published

2023-10-06

How to Cite

Fayed, R. H., Rashad, E. . ., El-Samannoudy , S. I., Elsherif, H. M. R., Aboul Ella, H., & Ismael, E. (2023). Mitigative Effect of Dietary Tinospora cordifolia and Andrographis paniculata on Health and Hepato-renal Expression of Caspase-3 and TNF-α of Broiler Chickens Fed on Aflatoxin and Ochratoxin Contaminated Diet. Journal of Advanced Veterinary Research, 13(8), 1668-1677. Retrieved from https://advetresearch.com/index.php/AVR/article/view/1469

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Section

Original Research

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