Biochemical Evaluation of some Natural Feed Additives against Dexamethasone-induced Metabolic Alterations in Rabbits

  • Mohamed Ahmed Kandeil Biochemistry Department, Faculty of Veterinary Medicine, Beni-Suef University, Egypt.
  • Eman Taha Mohammed Associate Professor, Biochemistry Department, Faculty of Veterinary Medicine, Beni-Suef University, Egypt
  • Omima I. Ali Biochemistry Department, Animal Health Research Institute, Giza, Egypt.
  • Asmaa M. Abd-Elrahman Researcher, Biochemistry, Nutritional Deficiency and Toxicology Department, Animal Health Research Institute, Giza, Egypt.

Abstract

Glucocorticoid therapy is limited by numerous metabolic adverse effects associated with long term exposure to excess doses. Therefore, the present study aims to determine the possible protective effects of date palm and/or Saccharomyces cerevisiae probiotics on dexamethasone-induced metabolic changes in rabbits. 25 healthy male white New Zealand rabbits were grouped into group 1 (control), group 2 (2 mg/kg bw/day dexamethasone I/M), group 3 (0.5 g/kg/day date palm flesh+2 mg/kg bw/day dexamethasone I/M), group 4 (1g/kg/day S. cerevisiae probiotic + 2 mg/kg bw/day dexamethasone I/M), group 5 (date palm flesh + S. cerevisiae probiotic + dexamethasone at the aforementioned doses). Dexamethasone injection resulted in marked increases (p≤0.05) in hepatic MDA concentration and catalase activity, as well as significant decreases in hepatic GSH concentration and body weight gain. The serum levels of glucose, lipid profile (TG, cholesterol, VLDL, LDL/HDL risk ratio), and liver function biomarkers (serum total proteins, albumin, ALT, ALP) showed significant variations (P≤0.05) between control and dexamethasone treated group. The ameliorative effect of date palm fruit and/or probiotics (S. cerevisiae) was markedly indicated by restoration of these tested parameters to near normalcy. Therefore, the co-treatment with date or S. cerevisiae could be considered of great interest as potential feed additives for reduction of the adverse metabolic effects induced by dexamethasone in rabbits.

Published
2019-07-04
How to Cite
KANDEIL, Mohamed Ahmed et al. Biochemical Evaluation of some Natural Feed Additives against Dexamethasone-induced Metabolic Alterations in Rabbits. Journal of Advanced Veterinary Research, [S.l.], v. 9, n. 3, p. 107-116, july 2019. ISSN 2090-6277. Available at: <https://advetresearch.com/index.php/AVR/article/view/384>. Date accessed: 18 july 2019.
Section
Original Research