Effects of Oral Administration of Atorvastatin or Fenofibrate on Hyperlipidemia Induced by Betamethasone Dipropionate Injection in Rabbits

Authors

  • Sameh El Nabtity Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
  • Naglaa Z. Eleiwa Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
  • Mohamed A. Kamel Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
  • Azza Galal Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
  • Aya A. Fahmy Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
  • Esraa M. Fahmy Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt

Keywords:

Hyperlipidemia, Cardiovascular diseases, Betamethasone dipropionate, Triglycerides, Cholesterol, low-density lipoproteins

Abstract

Betamethasone, a fluorinated and synthetic steroid, is a commonly used glucocorticoid. To our knowledge, no available studies exist concerning the hyperlipidemic effect of betamethasone dipropionate (BDP) in rabbits. Therefore, the current study was conducted to highlight the effects of intramuscular injection of BDP on lipid profile in rabbits, investigate the possible mechanism underlying the produced effects and evaluate the possible antihyperlipidemic effect of atorvastatin (ATR) and fenofibrate (FFB). For this purpose, twenty male New Zealand rabbits were classified into control, BDP (0.5 ml/kg B.wt/ IM/day/single dose), BDP+ATR; rabbits were IM injected with BDP, then they were orally given ATR (1.9 mg./kg. B.wt./ once/ day/ month) and group IV (BDP+FFB); rabbits were IM injected with BDP then they were orally given FFB (7.5 mg/kg B.wt/ once/ day/ month). The obtained result revealed that single IM injection of BDP produced a significant elevation in triglycerides, total cholesterol, LDL level with a significant decline in HDL in comparison to control group on the 3rd,7th,14th, 21st, 30th day of the experiment. On the 30th day of the experiment there was an increase in the ALT, AST, MDA, VCAM-1 as well as a significant decrease in TAC. Furthermore, BDP induced a significant increase in HMG-COA reductase gene expression and a significant decrease in lipoprotein lipase gene expression. Oral administration of ATR or FFB concurrently with BDP for a month succeeded in reducing the hyperlipidemia induced by BDP in rabbits.

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Published

2023-07-22

How to Cite

El Nabtity, S. ., Eleiwa, N. Z. ., Kamel, M. A. ., Galal, A. ., Fahmy, A. A. ., & Fahmy, E. M. . (2023). Effects of Oral Administration of Atorvastatin or Fenofibrate on Hyperlipidemia Induced by Betamethasone Dipropionate Injection in Rabbits . Journal of Advanced Veterinary Research, 13(6), 990-996. Retrieved from https://advetresearch.com/index.php/AVR/article/view/1402

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